Are you talking about inline diffuser or the bubble counter?
if bubble counter, just wait that co2 turn off and unscrew it.
if are you talking about inline diffuser located on outflow before lily pipes/spray bar, you have to remove the pipes from the tank and put the both side of the hose (attached to the inline diffuser) in a bucket. The water that is inside the hose will flow out in the bucket, i think its inevitable.