Not to be completely annoying
😉 but why not eSHa 2000 as per the link included above - the Pearl gourami looks to have a markedly similar lesion & seems to have responded favorably to the treatment
You might also try Seachem Kanaplex (if available)
If fish is eating, try feeding medicated food (I believe Seachem provides instruction on their website, note that the combined use of Focus does increase binding of the medication to food)

pretty much expresses my opinion of these 2 "medications" - I've yet to see any (research) evidence that these compounds affect actual fish pathogens - as opposed to some water column effects
ie the water column pathogens that were "treated" by M & P are not observed to be infectious agents in ornamental fish
🙄
There are numerous reports of fish reacting adversely (even fatalities) in response to M & P, especially when used in combination as per the manufacturer - hopefully there is finally a
caution on the label
🙁
I don't really vacuum the substrate as it sucks so much down the pipe - opinion?
😳 missed this
Not sure about the Colombo, but Tropica aquarium soil can be "lifted" into the syphon tube, allowed to swirl about, then clamp off the suction to drop the "cleaned" substrate back to earth
😀
If this doesn't work with Colombo, just carefully do a surface vacuum to remove debris.
Also rinse filter media (use conditioned tap water), especially any sponge, replace any filter floss - this along with daily water changes (even just 25%) is often as effective as many aquarium medications
tends to lead to increased organic load in the water column, which means more bacteria etc,
As above, increased water changes
🙂
It generally takes a week or 2 of frequent water changes