It goes straight out from the filter with about 5 inch of hose then straight to the spray bar outlet...The only way I can see it mattering is if there's an inverted loop in your hose (so like a hill), as CO2 could accumulate there.
If its making a noise like trapped air... is it not just trapped air? Are the inlines on the intake or the outlet? Did the noise start immediately after starting back up, or after a few hours?
It only happens when I put the co2 on and not the filter.